Tiered Mentoring Program Swimming through the genes: Zebrafish models unravel the mysteries of Rett syndrome Dr. Amber Kerstetter-Fogle, Research program director of Neurology and Complex Care at Summa Health, Akron

Rett syndrome, linked to mutations in the MECP2 genes, lead to severe cognitive and motor impairments.  Zebrafish are an ideal model for studying Rett syndrome due to their genetic tractability and rapid development.  Our research utilized a knock out model of MECP2 gene to simulate Rett like symptoms, included altered swimming behavior and neural defects, which helps in understanding the disease progression and identify potential drug targets.  This model will allow for high throughput drug screening and the ability to observe neurodevelopment in real time. 

Our lab is developing the translational model of Rett syndrome in zebrafish. This project involves animal husbandry techniques and zebrafish rearing.  We will be looking to expand this model and develop screening techniques for drug screening.  

Learning opportunities to gain the following skills: understanding of the scientific process and method, basic science skills, such as pipetting and aseptic techniques, writing proposals and processes, zebrafish animal husbandry and rearing, proficiency in Microsoft Office, behavioral testing, data analysis and literature review. 

Commitment:
Must complete Summa Health’s onboarding process, including health screening and background check, in a timely manner as part of a master research agreement. There will be a minimum of 5 hour/week expectation of a student. We will work around your classes and exam schedule but must be committed to moving the project forward.